We always check beds for signs of bedbugs or any other infestation before we settle into any hotel room. When we pulled back the sheets and mattress covers, we found very large and widespread red staining in the folds of the pillow-top mattresses, which is a strong indicator that this bed has either a previous or current bedbug infestation (the red stains come from bed bug feces, blood from bites, and the bugs themselves if squashed).
We immediately requested a new room, and when we went into the new room, we did the same inspection and found the same, in fact worse. We contacted hotels.com and they helped us negotiate a refund. We left and stayed at a trusted higher end hotel brand instead.
To be clear, we didn't ever see any ACTIVE infestation here, just signs of previous infestations, but it's clear that it has been widespread in the past, spanning the entire hotel, and the mattresses have not been changed out. They are well wrapped. You probably won't have a problem. But we were grossed out enough that we decided to leave and make other plans.
La Quinta gave us no grief and no hassle about cancelling our reservation. They were kind and apologetic.