Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area, a park located 30.2 mi (48.6 km) from the centre of St. Louis.
Broemmelsiek Park is just one of the places to see in Defiance, so why not enjoy the other things to explore during your travels? Amble around this family-friendly area's gardens or experience its festivals.
Historic Daniel Boone Home and Heritage Center is just one of the landmarks located 4.3 mi (7 km) from central Defiance, so you might want to stop by for a few pics during your trip.
You can enjoy a tasting or tour at Sugar Creek Winery during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
You can enjoy a tasting or tour at Yellow Farmhouse Winery during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Defiance be like during my vacation?
July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.
Why should I book my Defiance hotel through Hotels.com?
There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.
Find out more about Defiance
Find out more about Defiance
If you're looking to discover somewhere new, look no further than Defiance. Whether you're planning to stay for a night or for the week, the area around Defiance has accommodations to fit every need. Search for hotels in Defiance with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Defiance hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Defiance hotel deals are here with our lowest price guarantee.
