Nestled in the heart of St. Louis, 21C Museum Hotel St Louis offers a luxurious retreat with an indoor pool, coffee shop/cafe, and gym. Indulge in a massage at the spa or enjoy billiards at the bar while relishing cooked-to-order breakfast options.
Reviews
9.09.0 out of 10
Wonderful
Popular amenities
Pool
Spa
Bar
Gym
24/7 front desk
Parking available
Main amenities (12)
Daily housekeeping
Restaurant and bar/lounge
Indoor pool
Breakfast available
Fitness center
Steam room
Valet parking
Room service
Coffee shop/cafe
Spa services
Business center
Meeting rooms
Feel at home (6)
Premium TV channels
Daily housekeeping
Espresso maker
Blackout drapes/curtains
Pets allowed
Elevator
$156 nightly
The total price is $183
$183 total
Sep 14 - Sep 15
Total with taxes and fees
Room options
Available filters for rooms
Showing 15 of 15 rooms
Loft, 2 Queen Beds
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
431 sq ft
Sleeps 4
2 Queen Beds
Luxury Suite, 1 King Bed
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Separate bathtub and shower
Private bathroom
549 sq ft
Sleeps 2
1 King Bed
View all photos for Room (Bunk Bed)
Room (Bunk Bed)
8.08.0 out of 10
Very good
6 reviews
(6 reviews)
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Separate bedroom
Blackout drapes/curtains
Private bathroom
Bathrobes
237 sq ft
1 bedroom
Sleeps 2
1 Twin Bunk Bed
Deluxe Room, Accessible (Accessible)
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
269 sq ft
Sleeps 2
1 King Bed
Suite, 1 King Bed (Library)
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
732 sq ft
City view
Sleeps 2
1 King Bed
Suite, 1 King Bed (21C)
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Separate bathtub and shower
Private bathroom
1119 sq ft
Sleeps 2
1 King Bed
Deluxe Room, 1 Double Bed, Accessible
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
388 sq ft
Sleeps 4
1 Double Bed
View all photos for Deluxe Room, 1 King Bed
Deluxe Room, 1 King Bed
9.29.2 out of 10
Wonderful
68 reviews
(68 reviews)
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
309 sq ft
Sleeps 2
1 King Bed
Deluxe Suite, 1 Double Bed, Accessible
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
517 sq ft
Sleeps 2
1 Double Bed
View all photos for Deluxe Double Room, 2 Queen Beds
Deluxe Double Room, 2 Queen Beds
8.68.6 out of 10
Excellent
20 reviews
(20 reviews)
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
369 sq ft
Sleeps 4
2 Queen Beds
Deluxe Room, 1 Double Bed, Accessible
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
388 sq ft
Sleeps 4
1 Double Bed
View all photos for Room, 1 King Bed, Corner
Room, 1 King Bed, Corner
8.68.6 out of 10
Excellent
24 reviews
(24 reviews)
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
326 sq ft
City view
Sleeps 2
1 King Bed
View all photos for Suite, 1 King Bed
Suite, 1 King Bed
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
517 sq ft
Sleeps 2
1 King Bed
View all photos for Deluxe Suite, 1 King Bed
Deluxe Suite, 1 King Bed
9.29.2 out of 10
Wonderful
5 reviews
(5 reviews)
Highlights
Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout drapes/curtains
Separate bedroom
Private bathroom
Bathrobes
517 sq ft
Sleeps 2
1 King Bed
View all photos for Luxury Double Room, 2 Queen Beds
St. Louis Lambert Intl. Airport (STL) - 26 min drive
St. Louis, MO (SUS-Spirit of St. Louis) - 32 min drive
St. Louis Gateway Station - 14 min walk
Kirkwood Station - 24 min drive
8th and Pine Station - 13 min walk
Convention Center Station - 16 min walk
Stadium Station - 18 min walk
Restaurants
Budweiser Kiel Club - 6 min walk
City Museum Rooftop Cafe - 5 min walk
Rosalita's Cantina - 6 min walk
Medina Grill - 5 min walk
Idol Wolf - 1 min walk
About this property
21C Museum Hotel St Louis
21C Museum Hotel St Louis puts you in a great location, within just a 10-minute walk of City Museum and Enterprise Center. Guests indulge in massages, then grab a bite to eat at the coffee shop/cafe. Other features of this luxurious hotel include an indoor pool, a bar/lounge, and a fitness center. Fellow travelers say great things about the pool and helpful staff. Public transportation is close by: 8th and Pine Station is just 13 minutes by foot.
At a glance
DONE
Hotel size
104 rooms
DONE
Arriving/Leaving
Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21
Check-out time is 11:00 AM
DONE
Special check-in instructions
Front desk staff will greet guests on arrival at the property
DONE
Required at check-in
Credit card, debit card, or cash deposit required for incidental charges
Government-issued photo ID may be required
Minimum check-in age is 21
DONE
Children
No cribs (infant beds)
DONE
Pets
Pets allowed (dogs only)*
Service animals welcome
WIFI
Internet
Free WiFi in public areas
Free WiFi in rooms
LOCAL_PARKING
Parking
Onsite valet parking (USD 50 per day; includes in/out privileges)
DONE
Other information
Smoke-free property
Property amenities
Food and drink
Cooked-to-order breakfast (surcharge) each morning 6:30 AM–1:00 PM
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
Here's the breakdown, no surprises
Mandatory fees
You'll be asked to pay the following charges by the property at check-in or check-out. Fees may include applicable taxes:
Service fee: USD 5 per accommodation, per stay
Optional extras
Cooked-to-order breakfast is offered for an extra charge of approximately USD 10 to 25 per person
Pets
Service animals exempt from fees
Pets are allowed for an extra charge of USD 100 per accommodation, per stay
Parking
Valet parking costs USD 50 per day with in/out privileges
Pool, spa, & gym (if applicable)
Reservations are required for massage services and can be made by contacting the property before arrival at the number on the booking confirmation
Policies
Guests can rest easy knowing there's a smoke detector and outdoor lighting on site.
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).
This property accepts credit cards. Cash is not accepted.
Credit cards accepted: Visa, Mastercard, American Express
Also known as
21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)
Frequently asked questions
Does 21C Museum Hotel St Louis offer free cancellation for a full refund?
Yes, 21C Museum Hotel St Louis does have fully refundable room rates available to book on our site. If you’ve booked a fully refundable room rate, this can be cancelled up to a few days before check-in depending on the property's cancellation policy. Just make sure to check this property's cancellation policy for the exact terms and conditions.
Is there a pool at 21C Museum Hotel St Louis ?
Yes, there's an indoor pool.
Are pets allowed at 21C Museum Hotel St Louis ?
Yes, dogs are welcome. There's a charge of USD 100 per accommodation, per stay. Service animals are exempt from fees.
Is parking offered on site at 21C Museum Hotel St Louis ?
Yes. Valet parking costs USD 50 per day.
What are the check-in and check-out times at 21C Museum Hotel St Louis ?
Check-in start time: 4:00 PM; Check-in end time: 11:00 AM. Check-out time is 11:00 AM.
Is there an onsite casino at 21C Museum Hotel St Louis ?
No, this hotel doesn't have a casino, but Horseshoe St. Louis Casino (3-min drive) and Casino Queen (4-min drive) are both nearby.
What is there to do at 21C Museum Hotel St Louis and nearby?
21C Museum Hotel St Louis has an indoor pool and a steam room, as well as spa services.
Are there restaurants at or near 21C Museum Hotel St Louis ?
Yes, there's an onsite restaurant.
What's the area around 21C Museum Hotel St Louis like?
21C Museum Hotel St Louis is in Downtown West, a short 12-minute walk from St. Louis Union Station and 18 minutes' walk from Busch Stadium. Travelers love the hotel's prime location.
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21C Museum Hotel St Louis Reviews
Reviews
9.0
Wonderful
All reviews shown are from real guest experiences. Only travelers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.More informationOpens in a new window
9.2/10
Cleanliness
9.2/10
Staff & service
9.2/10
Amenities
9.4/10
Property conditions & facilities
9.2/10
Eco-friendliness
Popular mentions
Room
Service staff
Art
Bar
Restaurant
Food
Amenities
Ambience
Shower
Parking
What guests liked
Breakfast options were delicious and available at the on-site cafe and restaurant. (12 reviews)
From real guest reviews summarized by AI.
Reviews
10/10 Exceptional
Aug 29, 2025
Beautiful hotel with identity
This was a little gem in St Louis. Love the accessible art gallery, the great swimming pool for laps and the awesome bar staff. This is a boutique hotel with character.
Julien
Julien, 2-night trip
10/10 Exceptional
Aug 25, 2025
Restful sleep after a family outing in town
Very clean and comfortable stay. Great location downtown with an easy walk to many attractions. Wonderful food selections from the Concierge service. Valet and Desk Attendant were extremely welcoming and had a pleasant personality.
William
William, 1-night trip
10/10 Exceptional
Aug 16, 2025
We enjoyed our stay! Close to Busch Stadium which was our destination. Staff was friendly and extremely helpful. Valet parking was worth it.
Jennifer L
Jennifer L, 2-night trip
10/10 Exceptional
Jul 17, 2025
Great location, nice restaurant in the hotel. Friendly staff
Audra
Audra, 2-night trip
10/10 Exceptional
Aug 30, 2025
Everybody's great, but especially the valets!
The whole staff is always wonderful here. The bartenders are spectacular. But who really stands out is the valet staff. A++, above and beyond every single time. Thanks!
Susan
Susan, 1-night trip
10/10 Exceptional
Jun 30, 2025
The hotel is beautiful and the staff was very helpful.
Beth
Beth, 1-night trip
10/10 Exceptional
Jul 28, 2025
Art Deco at its Finest
This has been one of the best hotels I've been to in several years. Beautiful and clean with the the most beautiful art work around the whole hotel and the fact that it has its own Art Gallery is absolutely amazing.
Bruce
Bruce, 1-night trip
10/10 Exceptional
Jun 16, 2025
Amazing stay! Best hotel bar ever!!!
Hillary
Hillary, 3-night trip
10/10 Exceptional
Jul 12, 2025
Good stay
Najah
Najah, 1-night trip
8/10 Very good
Aug 26, 2025
Clean but pay to park
It was a nice hotel. It was a little discouraging that we had to pay to park after paying the price of the room. From the parking area (around back), you had to go to the front, then go up steps to enter the hotel. I just didn't love the setup. There are no ice machines, no vending, but they do have a bar and coffee shop. All and all it was a nice stay, but I don't know that I would want to stay again.
Beth
Beth, 2-night trip
6/10 Good
Aug 25, 2025
The sheets and comforter both had stains or something on both beds which we didn’t notice until the next morning…nasty!!!
Dawn
Dawn, 1-night trip
10/10 Exceptional
May 27, 2025
Good hotel located within walking distance of the ballpark, arch, and numerous other parks.
Robert
Robert, 2-night trip
10/10 Exceptional
May 12, 2025
Great place and cool decor.
Service was great and the hotel/museum is beautiful.
michelle
michelle, 1-night trip
10/10 Exceptional
Apr 15, 2025
Great hotel
Claudia
Claudia, 4-night trip
10/10 Exceptional
Apr 10, 2025
Great location, wonderful staff
Jessica
Jessica, 2-night trip
8/10 Very good
Aug 18, 2025
Stay was fine and the room was comfortable. We did have an issue at checkout with someone trying to charge drinks to our room. The parking situation is also less than ideal. 50 dollar valet parking and it was just a lot on the street that didnt seem very safe for your vehicle. There was only street parking or another unfenced lot behind the hotel that was paid parking for 30 dollars.
Verified traveler
1-night trip
10/10 Exceptional
May 12, 2025
Lovely historic hotel. Amenities - pool and fitness center were excellent. Walkable to the City Museum. Would definitely stay here again.
Cristina
Cristina, 1-night trip
10/10 Exceptional
Jun 3, 2025
So good
What a gem of a hotel! Great room, great service at the desk and by the valet Isabella. The pool/sauna/hot tub is excellent and rare to find at a modern downtown hotel. Cant wait to stay again!
Jamie
Jamie, 1-night trip
10/10 Exceptional
Apr 22, 2025
I always love staying at this hotel! The decor is beautiful and the drinks and food are top notch!
Jennifer
Jennifer, 1-night trip
8/10 Very good
Apr 26, 2025
Great place in St. Louis.
Emma
Emma, 1-night trip
10/10 Exceptional
May 6, 2025
Great gym and pool, fun atmosphere on main level
John
John, 1-night trip
10/10 Exceptional
May 29, 2025
Great location near downtown. Amazing staff! Great restaurant and coffee shop on the property. For those that don't know they also have an amazing art museum on the 2nd floor. Love the 21C hotel chain
Would love to see one of these in every city!
Jamie
Jamie, 1-night trip
10/10 Exceptional
Jun 29, 2025
21c St Louis
The room was nice and a great location. However the $50 parking fee wasn’t expected. And the $65 early check in fee was exorbitant.
Josh
Josh, 1-night trip
10/10 Exceptional
May 14, 2025
Spectacular interior! Good service. Would stay here again and highly recommend:)
Jessica
Jessica, 1-night trip
6/10 Good
Jul 25, 2025
Cool vibe
Cool atmosphere and vibe, however, the room was not the cleanest. Towels had stains on them, bedding as well. There were giant cobwebs in the vents and we didn't get clean towels when they cleaned the room.