Comfort Inn & Suites Sikeston I-55

Sikeston hotel with indoor pool

Choose dates to view prices

Where to?

Dates

December 2025

14

January 2026

Exterior - Comfort Inn & Suites Sikeston I-55 (Sikeston)

Desk, free WiFi, bed sheets, alarm clocks - Comfort Inn & Suites Sikeston I-55 (Sikeston)

Lobby - Comfort Inn & Suites Sikeston I-55 (Sikeston)

Indoor pool - Comfort Inn & Suites Sikeston I-55 (Sikeston)

Located off I-55, Comfort Inn & Suites Sikeston I-55 offers a welcoming retreat with an indoor pool and laundry facilities. Stay connected with in-room WiFi, get fit at the gym or conduct business in the center.

Very good

Popular amenities

Pet friendly
Gym
Laundry facilities
Free parking
Free WiFi

Main amenities (7)

Indoor pool
Fitness center
Business center
24-hour front desk
Air conditioning
Front-desk safe
Self-serve laundry

Feel at home (6)

Private bathroom
Cable/satellite TV service
Laundry facilities
Coffee/tea maker
Pets allowed
Elevator

$84 nightly

Dec 21 - Dec 22

Total with taxes and fees

Room options

Check availability for these dates

Tonight

Dec 14 - Dec 15

Tomorrow

Dec 15 - Dec 16

All rooms

2 beds

1 bed

Showing 5 of 5 rooms

Standard Room, 2 Queen Beds, Non Smoking

Very good

Highlights

Air conditioning

Refrigerator

Private bathroom

Coffee/tea maker

Cable/satellite channels

Desk

Sleeps 4
2 Queen Beds

Suite, 1 King Bed with Sofa bed, Non Smoking

Highlights

Air conditioning

Refrigerator

Sofa bed

Separate bedroom

Private bathroom

Coffee/tea maker

Cable/satellite channels

Desk

1 bedroom
Sleeps 4
1 King Bed and 1 Double Sofa Bed

Room, 1 King Bed, Accessible, Non Smoking

Wonderful

Highlights

Air conditioning

Private bathroom

Coffee/tea maker

Cable/satellite channels

Desk

Sleeps 2
1 King Bed

Room, 2 Queen Beds, Accessible, Non Smoking

Exceptional

Highlights

Air conditioning

Private bathroom

Coffee/tea maker

Cable/satellite channels

Desk

Sleeps 4
2 Queen Beds

Standard Room, 1 King Bed, Non Smoking

Very good

Highlights

Air conditioning

Refrigerator

Private bathroom

Coffee/tea maker

Cable/satellite channels

Desk

Sleeps 2
1 King Bed

Similar properties

Pool
Free breakfast
Pet friendly
Free parking

$71 nightly

Dec 21 - Dec 22

Total with taxes and fees

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About the neighborhood

109 Matthews Ln, Sikeston, MO, 63801

What's nearby

City of Miner Convention Center - 5 min walk - 0.4 km
Saint Francis Medical Center - 28 min drive - 57.8 km
Isle Casino Cape Girardeau - 33 min drive - 61.2 km
Southeast Missouri State University - 33 min drive - 62.0 km
Show Me Center - 34 min drive - 62.9 km

Getting around

Cairo, IL (CIR-Cairo Regional) - 29 min drive
Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 29 min drive

Restaurants

‪Lambert's Cafe - ‬17 min walk
‪Buffalo Wild Wings - ‬5 min drive
‪Pizza Inn - ‬2 min drive
‪Burger King - ‬4 min drive
‪McDonald's - ‬2 min walk

About this property

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55 is a great choice for a stay in Sikeston. The indoor pool is a great spot for a morning swim, and guests can get a workout in at the fitness center. Fellow travelers say great things about the helpful staff.

At a glance

Hotel size

- 64 rooms
- Arranged over 3 floors

Arriving/Leaving

- Check-in start time: 2:00 PM; Check-in end time: anytime
- Minimum check-in age: 21
- Check-out time is 11:00 AM

Special check-in instructions

- Front desk staff will greet guests on arrival at the property
- Information provided by the property may be translated using automated translation tools

Required at check-in

- Credit card, debit card, or cash deposit required for incidental charges
- Government-issued photo ID may be required
- Minimum check-in age is 21

Children

- No cribs (infant beds)

Pets

- Pets allowed (dogs and cats only, 2 total, up to 20 lbs per pet)*
- Service animals welcome
- Specific rooms only*

Internet

- Free WiFi in public areas
- Free WiFi in rooms

Parking

- Free onsite self parking
- Wheelchair-accessible parking on site

Property amenities

Working away

Business center

Services

24-hour front desk
Laundry facilities

Facilities

Safe-deposit box at front desk
Fitness center
An indoor pool

Accessibility

Elevator
Wheelchair-accessible parking
Wheelchair-accessible registration desk

Room amenities

Be entertained

Cable/satellite TV channels

Home comfort

Air conditioning
Coffee/tea maker

Sleep well

Alarm clock
Bed sheets provided

Freshen up

Private bathroom
Bathtub or shower
Towels

Stay connected

Desk
Free WiFi
Phone

Fees & policies

Pets

Service animals exempt from fees
Pets are allowed for an extra charge of USD 20 per pet, per night

Policies

This property accepts credit cards. Cash is not accepted.

Credit cards accepted: Visa, American Express, Discover, JCB International, Carte Blanche

This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice).

Also known as

Comfort Inn Sikeston Hotel

Comfort Inn Sikeston

Frequently asked questions

Does Comfort Inn & Suites Sikeston I-55 offer free cancellation for a full refund?

Yes, Comfort Inn & Suites Sikeston I-55 does have fully refundable room rates available to book on our site. If you’ve booked a fully refundable room rate, this can be cancelled up to a few days before check-in depending on the property's cancellation policy. Just make sure to check this property's cancellation policy for the exact terms and conditions.

Is there a pool at Comfort Inn & Suites Sikeston I-55?

Yes, there's an indoor pool.

Are pets allowed at Comfort Inn & Suites Sikeston I-55?

Yes, cats and dogs are welcome, with a limit of 2 total and maximum weight of 20 lbs per pet. There's a charge of USD 20 per pet, per night. Service animals are exempt from fees.